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Generative artificial intelligence

Generative artificial intelligence (GenAI) refers to a class of artificial intelligence systems, typically built on large language models and related generative architectures, that can create new content such as text, images, audio, or video in response to prompts or other inputs.

Where the papers sit

15 papers from the last 6 months study generative artificial intelligence directly · updated from PubMed 1 Oct 2026

Study type 0 clinical trials · 2 observational · 13 human data

Themes one subject · 1 paradigm shift · 1 new direction

Those 15 are all about one subject.

  • Healthcare AI Implementation

    Clinical support, nursing practice and medical education are the main settings for generative AI adoption. Recurring questions concern accuracy, empathy, readability, usefulness, perceived risk, workload and burnout for patients and clinicians. Exploratory, vignette-based and mixed-methods studies suggest potential for symptom support, discharge planning, clinical reasoning and evidence-based practice, but also expose mismatches with real-world primary care. Patient-informed design, professional oversight and outcome-based validation remain necessary before routine use.

    15 papers

PARADIGM SHIFT

Generative AI performance cannot be treated as a proxy for safe, effective clinical usefulness

The discharge-planning study on GPT-4 versus registered nurses, the primary-care perspective on large language models, and the physiology-education study comparing AI-assisted with conventional work all challenge the assumption that stronger output performance or AI assistance is sufficient evidence of superiority. In discharge planning, GPT-4 produced more comprehensive information but introduced safety risks and was inferior to nurses in empathy and readability 42655921Aug; in primary care, hospital-based benchmarks were judged misaligned with multimorbidity, continuity, cultural and linguistic variation, and other real-world conditions 42762495Sep; and in physiology education, AI-assisted reports did not significantly outperform reports produced with conventional resources 42085322May. The resulting change is evaluative rather than merely technical: generative AI must be judged by context-specific safety, relational quality, verification, and actual task benefit, rather than by comprehensiveness, benchmark scores, or the assumption that assistance itself improves performance.

NEW DIRECTION

Generative AI becomes a programmer of scientific image-analysis tools

The adaptive-optics flood-illumination ophthalmoscopy study in healthy participants and patients with Stargardt disease gives GPT-4 a role not otherwise represented in the set: generating executable R code for a domain-specific scientific image-analysis pipeline 42735400Sep. GPT-4 was used to create and iteratively refine a script for image preprocessing and analysis, producing a functional but explicitly nonvalidated tool. This extends generative AI beyond producing clinical information, educational material, workflow documents, or decision-support content to constructing research instrumentation for scalable quantitative analysis, while making independent validation part of the resulting workflow.

Papers

The 15 papers from the last 6 months that study generative artificial intelligence directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.

By theme

Healthcare AI Implementation (15)
  1. Exploring young adult cancer survivors' perspectives on generative AI chatbots for symptom support. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 22 Sept 2026 PMID 42773243
  2. Misaligned by design: evaluating and deploying generative AI for the real-world conditions of primary care: a Nordic and European perspective. Scandinavian journal of primary health care · 19 Sept 2026 PMID 42762495
  3. Adaptive Optics Image Analysis Using Generative AI (GPT-4) Scripting: Exploratory Study. JMIR formative research · 14 Sept 2026 PMID 42735400
  4. Generative AI Use, Perceived Usefulness, Perceived Risk, and Physician Burnout and Fulfillment Among Chinese Physicians: Mixed Methods Multiregional Study. Journal of medical Internet research · 11 Sept 2026 PMID 42727068
  5. Advancing Nursing Cognitive Capacity Through Generative AI and Immersive VR as a Structural Intervention for Burnout and Administrative Burden. Nursing administration quarterly · 27 Aug 2026 PMID 42659607
  6. Evaluating the Accuracy, Empathy, and Readability of Generative AI Versus Registered Nurses in Discharge Planning: A Vignette-Based Study. Nursing open · 27 Aug 2026 PMID 42655921
  7. The Value Opportunity from Artificial Intelligence in U.S. Health Care Spending. NEJM catalyst innovations in care delivery · 19 Aug 2026 PMID 42615592
  8. Integrating Generative AI Into Clinical Reasoning Education for Medical Students: Mixed Methods Study. JMIR medical education · 13 Aug 2026 PMID 42594250
  9. Harnessing Artificial Intelligence to Support Evidence-based Practice: A Clinical Nurse Specialist Case Application. Clinical nurse specialist CNS · 5 Aug 2026 PMID 42555769
  10. Patient- and Caregiver-Informed Considerations for the Design and Implementation of Generative AI-Supported Patient-Centered Clinical Decision Support: Qualitative Study. Journal of medical Internet research · 14 Jul 2026 PMID 42447289
  11. Commentary on the fundamentals and development of artificial intelligence models in the life sciences and best research practices. Journal of computer-aided molecular design · 3 Jul 2026 PMID 42397470
  12. Edentulous space classification and planning of clasp-retained removable dentures using generative artificial intelligence. Quintessence international (Berlin, Germany : 1985) · 26 Jun 2026 PMID 42359963
  13. Development of the ChatGPT Attitude Scale for Nursing Education: A Methodological Study. Nursing & health sciences · 25 May 2026 PMID 42185856
  14. Emulated trial of artificial intelligence use and subsequent depressive outcomes in a survey of US adults. BMJ mental health · 13 May 2026 PMID 42128453
  15. Comparing conventional and generative AI-assisted task performance in physiology education. Advances in physiology education · 5 May 2026 PMID 42085322

By study type

Observational studies and case reports (2)
  1. Generative AI Use, Perceived Usefulness, Perceived Risk, and Physician Burnout and Fulfillment Among Chinese Physicians: Mixed Methods Multiregional Study. Journal of medical Internet research · 11 Sept 2026 PMID 42727068
  2. Evaluating the Accuracy, Empathy, and Readability of Generative AI Versus Registered Nurses in Discharge Planning: A Vignette-Based Study. Nursing open · 27 Aug 2026 PMID 42655921
Human data, design not indexed (13)
  1. Exploring young adult cancer survivors' perspectives on generative AI chatbots for symptom support. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 22 Sept 2026 PMID 42773243
  2. Misaligned by design: evaluating and deploying generative AI for the real-world conditions of primary care: a Nordic and European perspective. Scandinavian journal of primary health care · 19 Sept 2026 PMID 42762495
  3. Adaptive Optics Image Analysis Using Generative AI (GPT-4) Scripting: Exploratory Study. JMIR formative research · 14 Sept 2026 PMID 42735400
  4. Advancing Nursing Cognitive Capacity Through Generative AI and Immersive VR as a Structural Intervention for Burnout and Administrative Burden. Nursing administration quarterly · 27 Aug 2026 PMID 42659607
  5. The Value Opportunity from Artificial Intelligence in U.S. Health Care Spending. NEJM catalyst innovations in care delivery · 19 Aug 2026 PMID 42615592
  6. Integrating Generative AI Into Clinical Reasoning Education for Medical Students: Mixed Methods Study. JMIR medical education · 13 Aug 2026 PMID 42594250
  7. Harnessing Artificial Intelligence to Support Evidence-based Practice: A Clinical Nurse Specialist Case Application. Clinical nurse specialist CNS · 5 Aug 2026 PMID 42555769
  8. Patient- and Caregiver-Informed Considerations for the Design and Implementation of Generative AI-Supported Patient-Centered Clinical Decision Support: Qualitative Study. Journal of medical Internet research · 14 Jul 2026 PMID 42447289
  9. Commentary on the fundamentals and development of artificial intelligence models in the life sciences and best research practices. Journal of computer-aided molecular design · 3 Jul 2026 PMID 42397470
  10. Edentulous space classification and planning of clasp-retained removable dentures using generative artificial intelligence. Quintessence international (Berlin, Germany : 1985) · 26 Jun 2026 PMID 42359963
  11. Development of the ChatGPT Attitude Scale for Nursing Education: A Methodological Study. Nursing & health sciences · 25 May 2026 PMID 42185856
  12. Emulated trial of artificial intelligence use and subsequent depressive outcomes in a survey of US adults. BMJ mental health · 13 May 2026 PMID 42128453
  13. Comparing conventional and generative AI-assisted task performance in physiology education. Advances in physiology education · 5 May 2026 PMID 42085322