Dopamine
Dopamine is a catecholamine neurotransmitter with central roles in motor control, motivation, reward processing, endocrine regulation, and several peripheral physiological processes.
Dopamine is a catecholamine neurotransmitter with central roles in motor control, motivation, reward processing, endocrine regulation, and several peripheral physiological processes. In the nervous system, its biological effects are mediated primarily through dopamine receptors, and altered dopamine signaling is a hallmark of multiple neurological and psychiatric disorders, especially Parkinson’s disease. Dopamine is also widely used as a biomarker of neurotransmitter balance and dopaminergic neuron function in experimental and clinical research.
In biomedical and translational contexts, dopamine is studied both as an endogenous signaling molecule and as a therapeutic target or readout of disease state. Recent work has focused on dopamine depletion, dopamine metabolism, dopamine receptor biology, and methods for measuring or restoring dopamine levels in models of neurodegeneration, metabolic disease, and bioelectronic sensing systems.
- Large-scale prospective evaluation of co-folding across hundreds of Mac1-ligand complexes and three virtual screens. PMID 42862171
Where the papers sit
12 papers from the last 6 months study dopamine directly
Study type 0 clinical trials · 4 human data · 6 preclinical · 2 unclassified
Themes no clear themes · 1 new direction
Those 12 do not share a common subject.
-
Dopamine is examined across molecular modeling, neuropsychiatric biology, cancer immunity, biomaterials, stimulant pharmacology, and chemical sensing. Recurring applications include measuring neurotransmitter imbalance, probing dopamine homeostasis and redox signaling, and designing adhesive or electrochemical materials. Other studies address pyroptosis in colorectal cancer, Parkinson’s disease biomarkers, restless legs syndrome, and drug transporter activity. The subjects and endpoints are too disparate to support a shared biological direction.
Tumoral dopamine acts as an immunometabolic effector in colorectal cancer
The colorectal cancer models studied in the AMER1 paper show that dopamine is not merely a neuronal signal, disease-associated biomarker, or grafted chemical functional group, as in the other abstracts, but a tumor-secreted regulator of the immune microenvironment. AMER1 preserves dopa decarboxylase and thereby sustains tumoral dopamine secretion; loss of AMER1 creates a localized dopamine void, whereas dopamine drives niche remodeling associated with tumor-cell pyroptosis and CD8+ T-cell immunity. This assigns dopamine a previously absent role as a tumor-derived signal linking cancer-cell metabolism to antitumor immune organization 42546913Aug.
Papers
The 12 papers from the last 6 months that study dopamine directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
No clear themes (12)
- Large-scale prospective evaluation of co-folding across hundreds of Mac1-ligand complexes and three virtual screens. eLife · 12 Oct 2026 PMID 42862171
- Catechol-O-methyltransferase connects dopamine homeostasis to redox signaling, metal homeostasis, and protein folding in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America · 16 Sept 2026 PMID 42748150
- Brain cognition gaps reveal associations with dopamine and factors related to brain health through artificial intelligence prediction of functional connectome. eLife · 2 Sept 2026 PMID 42684829
- Single-Helical Dopamine-g-Curdlan Hydrogels Showing High Adhesiveness and Injectability. ACS applied bio materials · 14 Aug 2026 PMID 42600106
- Tumoral AMER1 driven dopamine synthesis triggers cancer cell pyroptosis and licenses CD8+ T cell immunity in colorectal cancer. Cancer letters · 3 Aug 2026 PMID 42546913
- A self-crosslinking powder based on carboxymethyl chitosan and guar gum with free radical scavenging for rapid hemostasis and promotion of wound healing. Carbohydrate polymers · 23 Jul 2026 PMID 42493083
- Comprehensive in vitro profiling of traditional and emerging stimulants at monoamine transporters and the 5-HT2A receptor. British journal of pharmacology · 14 Jul 2026 PMID 42449077
- Gas-phase recognition by a dopamine-selective cyclic tetrapeptide in the analysis of plant extracts. Analytical methods : advancing methods and applications · 7 Jul 2026 PMID 42411264
- Label-free paper-based electrochemical aptasensor with tunable selectivity for assessing neurotransmitter imbalance in Alzheimer's disease. Mikrochimica acta · 7 May 2026 PMID 42095905
- Aerobic exercise as a non-pharmacological approach to restless legs syndrome: Evidence from an ID-induced model. Life sciences · 2 May 2026 PMID 42069295
- Personalized metabolite biomarker predictions reveal heterogeneous characteristics of Parkinson's disease. NPJ Parkinson's disease · 21 Apr 2026 PMID 42014729
- Covalent Immobilization of Hydrogels on Carbon Fiber Microelectrodes for the Determination of Dopamine in the Living Mouse Brain. ACS applied bio materials · 16 Apr 2026 PMID 41988909
By study type
Human data, design not indexed (4)
- Large-scale prospective evaluation of co-folding across hundreds of Mac1-ligand complexes and three virtual screens. eLife · 12 Oct 2026 PMID 42862171
- Brain cognition gaps reveal associations with dopamine and factors related to brain health through artificial intelligence prediction of functional connectome. eLife · 2 Sept 2026 PMID 42684829
- Comprehensive in vitro profiling of traditional and emerging stimulants at monoamine transporters and the 5-HT2A receptor. British journal of pharmacology · 14 Jul 2026 PMID 42449077
- Label-free paper-based electrochemical aptasensor with tunable selectivity for assessing neurotransmitter imbalance in Alzheimer's disease. Mikrochimica acta · 7 May 2026 PMID 42095905
Preclinical: animal, cell and lab studies (6)
- Catechol-O-methyltransferase connects dopamine homeostasis to redox signaling, metal homeostasis, and protein folding in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America · 16 Sept 2026 PMID 42748150
- Single-Helical Dopamine-g-Curdlan Hydrogels Showing High Adhesiveness and Injectability. ACS applied bio materials · 14 Aug 2026 PMID 42600106
- A self-crosslinking powder based on carboxymethyl chitosan and guar gum with free radical scavenging for rapid hemostasis and promotion of wound healing. Carbohydrate polymers · 23 Jul 2026 PMID 42493083
- Gas-phase recognition by a dopamine-selective cyclic tetrapeptide in the analysis of plant extracts. Analytical methods : advancing methods and applications · 7 Jul 2026 PMID 42411264
- Aerobic exercise as a non-pharmacological approach to restless legs syndrome: Evidence from an ID-induced model. Life sciences · 2 May 2026 PMID 42069295
- Covalent Immobilization of Hydrogels on Carbon Fiber Microelectrodes for the Determination of Dopamine in the Living Mouse Brain. ACS applied bio materials · 16 Apr 2026 PMID 41988909
Unclassified: not yet indexed with MeSH (2)
- Tumoral AMER1 driven dopamine synthesis triggers cancer cell pyroptosis and licenses CD8+ T cell immunity in colorectal cancer. Cancer letters · 3 Aug 2026 PMID 42546913
- Personalized metabolite biomarker predictions reveal heterogeneous characteristics of Parkinson's disease. NPJ Parkinson's disease · 21 Apr 2026 PMID 42014729
Written from 12 PubMed abstracts, each one listed by PMID above. Published: 2026-06-15. Last written: 2026-09-18 by GPT. Drafted by language models from published abstracts; not medical advice.