Carbonic anhydrase (CA)
Carbonic anhydrase refers to a family of zinc-containing metalloenzymes that catalyze the reversible interconversion of carbon dioxide and water to bicarbonate and protons.
Carbonic anhydrase refers to a family of zinc-containing metalloenzymes that catalyze the reversible interconversion of carbon dioxide and water to bicarbonate and protons. This reaction is central to physiological acid–base balance, CO2 transport, ion transport, and fluid secretion. Carbonic anhydrases are widely expressed across tissues and include multiple isoforms with distinct cellular localizations and biological roles.
From a biomedical perspective, carbonic anhydrases are important because altered isoform expression can contribute to disease processes, including tumor progression and dysregulated pH homeostasis. In drug discovery, they are established targets for both inhibition and activation strategies. Tumor-associated isoforms such as CA IX and CA XII are especially relevant in oncology, while brain-associated isoforms such as CA VII are being explored as targets for selective activation. Because these enzymes sit at the interface of metabolism, pH regulation, and cellular adaptation, they are also of interest in biomaterials and biosensing applications.
Where the papers sit
9 papers from the last 6 months study Carbonic anhydrase (CA) directly · updated from PubMed 5 Oct 2026
Study type 0 clinical trials · 9 preclinical
Themes one subject
Those 9 are all about one subject.
-
Carbonic Anhydrase Biology and Inhibition
Carbonic anhydrase inhibition remains the shared focus, spanning isoform-selective sulfonamides, dual-target anticancer compounds, and activity-monitoring tools. Several studies pursue CA IX/XII or CA II selectivity and antiproliferative effects in colorectal and renal cancers. Other work links inhibition to neuronal H+ and Cl− transients or examines aggregation and responsive sensing. The breadth supports continued inhibitor design and functional characterization rather than a single therapeutic direction.
Papers
The 9 papers from the last 6 months that study Carbonic anhydrase (CA) directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Carbonic Anhydrase Biology and Inhibition (9)
- PMID 41905101
- Effect of carbonic anhydrase inhibitor on H+- and Cl--transients and epileptiform activity in brain slices of ClopHensor-expressing transgenic mice. Neuroscience · 13 Jul 2026 PMID 42442454
- Investigating the Inhibitory Properties of Diazo and Pyrazole-Carboxamide-Linked Benzenesulfonamides Against Carbonic Anhydrase Isoforms I, II, IX, and XII. ChemMedChem · 7 Jul 2026 PMID 42410713
- Rational design and synthesis of pyrazole-based sulfonamides as dual carbonic anhydrase and PRAK-targeting anticancer agents. Bioorganic chemistry · 29 Jun 2026 PMID 42372456
- Molecular signature exploration of novel Pyrazolone-derived sulfonamides against colorectal Cancer: Synthesis, biological profiling and computational modeling. Bioorganic chemistry · 27 Jun 2026 PMID 42364381
- Design and Synthesis of Bendamustine-Carbonic Anhydrase Inhibitors with Antiproliferative Effects in Clear Cell Renal Cell Carcinoma. Journal of medicinal chemistry · 24 Jun 2026 PMID 42339601
- Discovery of Subnanomolar and Highly Selective Carbonic Anhydrase II Inhibitors Featuring L-Shaped Scaffolds via Active-Site-Matched Fragment Growing. Journal of medicinal chemistry · 15 Jun 2026 PMID 42290333
- Glutamate binding perturbs structure-function integrity of carbonic anhydrase and promotes its aggregation: Implications of dysregulated metabolite levels in neurodegeneration. International journal of biological macromolecules · 11 Jun 2026 PMID 42276475
- Conductive Dual Dynamic Cross-Linked H+-Responsive Hydrogel for Electrochemical Sensitive Monitoring of Carbonic Anhydrase Activity. Analytical chemistry · 9 May 2026 PMID 42104951
By study type
Preclinical: animal, cell and lab studies (9)
- Effect of carbonic anhydrase inhibitor on H+- and Cl--transients and epileptiform activity in brain slices of ClopHensor-expressing transgenic mice. Neuroscience · 13 Jul 2026 PMID 42442454
- Investigating the Inhibitory Properties of Diazo and Pyrazole-Carboxamide-Linked Benzenesulfonamides Against Carbonic Anhydrase Isoforms I, II, IX, and XII. ChemMedChem · 7 Jul 2026 PMID 42410713
- Rational design and synthesis of pyrazole-based sulfonamides as dual carbonic anhydrase and PRAK-targeting anticancer agents. Bioorganic chemistry · 29 Jun 2026 PMID 42372456
- Molecular signature exploration of novel Pyrazolone-derived sulfonamides against colorectal Cancer: Synthesis, biological profiling and computational modeling. Bioorganic chemistry · 27 Jun 2026 PMID 42364381
- Design and Synthesis of Bendamustine-Carbonic Anhydrase Inhibitors with Antiproliferative Effects in Clear Cell Renal Cell Carcinoma. Journal of medicinal chemistry · 24 Jun 2026 PMID 42339601
- Discovery of Subnanomolar and Highly Selective Carbonic Anhydrase II Inhibitors Featuring L-Shaped Scaffolds via Active-Site-Matched Fragment Growing. Journal of medicinal chemistry · 15 Jun 2026 PMID 42290333
- Glutamate binding perturbs structure-function integrity of carbonic anhydrase and promotes its aggregation: Implications of dysregulated metabolite levels in neurodegeneration. International journal of biological macromolecules · 11 Jun 2026 PMID 42276475
- One destination, three routes: Tacrine-Celecoxib hybrids targeting cholinesterases, COX-2, and carbonic anhydrases in cognitive impairment linked to metabolic dysfunction. European journal of medicinal chemistry · 26 May 2026 PMID 42190432
- Conductive Dual Dynamic Cross-Linked H+-Responsive Hydrogel for Electrochemical Sensitive Monitoring of Carbonic Anhydrase Activity. Analytical chemistry · 9 May 2026 PMID 42104951
Written from 9 PubMed abstracts, each one listed by PMID above. Published: 2026-06-24. Last written: 2026-07-29 by GPT. Drafted by language models from published abstracts; not medical advice.