Nirsevimab
Nirsevimab is a long-acting monoclonal antibody used for the prevention of respiratory syncytial virus (RSV) lower respiratory tract disease in infants.
Nirsevimab is a long-acting monoclonal antibody used for the prevention of respiratory syncytial virus (RSV) lower respiratory tract disease in infants. It is designed as an immunoprophylactic therapy rather than a traditional vaccine: instead of stimulating the host to generate its own antibody response, it provides immediate passive protection through direct administration of an RSV-neutralizing antibody. Its clinical role is especially important in early infancy, when the risk of severe RSV disease is highest and when active immune responses may be less predictable.
Biologically, nirsevimab targets the RSV fusion (F) protein in its prefusion conformation, thereby blocking viral entry into host cells. Because it has been engineered for extended half-life, a single dose can provide protection across much of the RSV season. In recent public health practice, nirsevimab has been discussed alongside maternal RSVpreF vaccination as part of broader infant RSV prevention strategies.
Where the papers sit
22 papers from the last 6 months study nirsevimab directly · updated from PubMed 10 Oct 2026
Study type 1 clinical trial · 14 observational · 7 human data
Themes 4 themes · 1 new direction
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Infant RSV Prevention
Infant RSV prevention is being compared across nirsevimab, maternal RSVpreF vaccination, and combined strategies. Real-world studies focus on protection duration and reductions in RSV-related hospitalization among high-risk infants. Economic analyses increasingly weigh population-wide immunization against targeted use. Breakthrough RSV-B infections raise a continuing concern about nirsevimab resistance.
8 papers · 36.4%
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RSV Immunization Programs
RSV immunization programs are being judged by coverage, uptake, safety, and cost-effectiveness. Nirsevimab and maternal RSVpreF vaccination are modelled as separate or hybrid approaches for preventing infant disease. Implementation studies identify newborn uptake and pediatrician knowledge as practical constraints. Post-licensure surveillance is expanding safety assessment to children aged 0–24 months.
6 papers · 27.3%
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RSV Immunization Acceptance
RSV immunization decisions center on acceptance, product choice, timing, and post-licensure safety. Surveys examine pregnant women’s preferences for maternal vaccination, postpartum acceptance of nirsevimab, and pediatricians’ knowledge of available products. Policy modelling compares seasonal with year-round infant immunization to reduce hospitalizations. Early program reports and Canadian surveillance are adding practical uptake and safety evidence.
6 papers · 27.3%
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RSV Prevention Outcomes
RSV prevention is being measured through outcomes beyond infection alone, especially hospitalization and acute otitis media. Interrupted time-series data associate nirsevimab with fewer acute otitis media infections in infants. Multicentre studies report reductions in pediatric RSV hospitalizations after regional immunization, but the size of benefit varies between settings. Heterogeneous effects remain an important question for program evaluation.
2 papers · 9.1%
Nirsevimab becomes an object of evolutionary resistance surveillance, not only an infant-prevention intervention
The French multicentre study of RSV-B breakthrough infections examines nirsevimab escape using genotypic and phenotypic methods rather than evaluating nirsevimab primarily as an infant-prevention product. It identifies breakthrough RSV-B infection and possible resistance emergence as the central problem, extending nirsevimab’s role to the surveillance of antibody escape and the durability of its conserved prefusion-F target 42229496Jun.
Papers
The 22 papers from the last 6 months that study nirsevimab directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Infant RSV Prevention (8)
- Effectiveness of nirsevimab and maternal RSVpreF vaccination against infant hospitalization across the island of Ireland. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 6 Aug 2026 PMID 42562126
- Effectiveness of RSV Prevention Strategies in US Infants: 2024-2025. Pediatrics · 3 Aug 2026 PMID 42547085
- Cost-benefit analysis of nirsevimab for respiratory syncytial virus prevention in infants: a population-based study. European journal of pediatrics · 3 Jul 2026 PMID 42399582
- Respiratory syncytial virus outcomes and duration of protection following nirsevimab administration in high-risk infants: a real-world study under year-round epidemic circulation in Japan. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 23 Jun 2026 PMID 42336142
- Cost-effectiveness and public health impact of RSV immunization for all infants in Japan: a mixed strategy with nirsevimab and RSVpreF. Expert review of vaccines · 23 Jun 2026 PMID 42334170
- Real-world emergence of nirsevimab resistance in breakthrough infections with respiratory syncytial virus-B: a multicentre observational study in France. The Lancet. Microbe · 2 Jun 2026 PMID 42229496
- Effectiveness of nirsevimab immunisation after birth versus RSVpreF maternal vaccination in preventing RSV-related hospitalisations in infants: a population-based retrospective cohort study. The Lancet. Child & adolescent health · 10 May 2026 PMID 42107385
- Maternal RSV Vaccination, Infant Nirsevimab, or Both: Interim Analysis of a Randomized Trial. Pediatrics · 3 May 2026 PMID 42070784
RSV Immunization Programs (6)
- Safety of nirsevimab in children aged 0-24 months: Analysis based on EudraVigilance data (2023-2025). Human vaccines & immunotherapeutics · 9 Oct 2026 PMID 42851207
- Uptake and predictors of newborn respiratory syncytial virus (RSV) immunisation with nirsevimab in Ireland's national pilot programme: a cross-sectional study. BMJ open · 22 Jun 2026 PMID 42331576
- Economic evaluation of a bivalent respiratory syncytial virus prefusion F vaccine for maternal vaccination in Sweden: cost-effectiveness and budget impact. Journal of medical economics · 8 Jun 2026 PMID 42258348
- Infant respiratory syncytial virus (RSV) immunisation coverage in an Australian regional area, 1 May 2024 - 31 October 2025. Communicable diseases intelligence (2018) · 25 May 2026 PMID 42184438
- Modelling the impact of long-acting monoclonal antibody, maternal vaccine and hybrid programs of RSV immunisation in temperate Western Australia. Vaccine · 23 May 2026 PMID 42176437
- Knowledge, attitudes, and practices of pediatricians in Crete, Greece, regarding RSV immunization: a cross-sectional study. European journal of pediatrics · 27 Apr 2026 PMID 42043589
RSV Immunization Acceptance (6)
- Comparing the potential impacts of seasonal immunisation against year-round immunisation to prevent RSV infant hospitalisations in Japan: A modelling study. Vaccine · 26 Aug 2026 PMID 42648051
- Pediatricians' attitudes and knowledge of RSV immunization products: A multi-country cross-sectional survey. PloS one · 17 Aug 2026 PMID 42607062
- Acceptance of the respiratory syncytial virus infant monoclonal antibody nirsevimab among post-partum women in Italy. Human vaccines & immunotherapeutics · 10 Jun 2026 PMID 42268596
- Acceptability and preferences regarding RSV immunisation during pregnancy: a cross-sectional study in diverse global settings. Vaccine · 7 Jun 2026 PMID 42251842
- First year of nirsevimab use in Argentina (2025): Report from a private vaccination center. Archivos argentinos de pediatria · 26 May 2026 PMID 42189590
- Post-licensure safety of nirsevimab from the Canadian National Vaccine Safety (CANVAS) network. Human vaccines & immunotherapeutics · 28 Apr 2026 PMID 42048598
RSV Prevention Outcomes (2)
- Nirsevimab reduced acute otitis media infections in infants-a nationwide interrupted time-series analysis. European journal of pediatrics · 9 Oct 2026 PMID 42855657
- Heterogeneous reduction in pediatrics RSV hospitalizations following regional nirsevimab immunization strategies: a multicenter study. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 27 Aug 2026 PMID 42660409
By study type
Clinical trials (1)
- Maternal RSV Vaccination, Infant Nirsevimab, or Both: Interim Analysis of a Randomized Trial. Pediatrics · 3 May 2026 PMID 42070784
Observational studies and case reports (14)
- Nirsevimab reduced acute otitis media infections in infants-a nationwide interrupted time-series analysis. European journal of pediatrics · 9 Oct 2026 PMID 42855657
- Heterogeneous reduction in pediatrics RSV hospitalizations following regional nirsevimab immunization strategies: a multicenter study. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 27 Aug 2026 PMID 42660409
- Pediatricians' attitudes and knowledge of RSV immunization products: A multi-country cross-sectional survey. PloS one · 17 Aug 2026 PMID 42607062
- Effectiveness of nirsevimab and maternal RSVpreF vaccination against infant hospitalization across the island of Ireland. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 6 Aug 2026 PMID 42562126
- Cost-benefit analysis of nirsevimab for respiratory syncytial virus prevention in infants: a population-based study. European journal of pediatrics · 3 Jul 2026 PMID 42399582
- Respiratory syncytial virus outcomes and duration of protection following nirsevimab administration in high-risk infants: a real-world study under year-round epidemic circulation in Japan. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 23 Jun 2026 PMID 42336142
- Cost-effectiveness and public health impact of RSV immunization for all infants in Japan: a mixed strategy with nirsevimab and RSVpreF. Expert review of vaccines · 23 Jun 2026 PMID 42334170
- Uptake and predictors of newborn respiratory syncytial virus (RSV) immunisation with nirsevimab in Ireland's national pilot programme: a cross-sectional study. BMJ open · 22 Jun 2026 PMID 42331576
- Acceptance of the respiratory syncytial virus infant monoclonal antibody nirsevimab among post-partum women in Italy. Human vaccines & immunotherapeutics · 10 Jun 2026 PMID 42268596
- Acceptability and preferences regarding RSV immunisation during pregnancy: a cross-sectional study in diverse global settings. Vaccine · 7 Jun 2026 PMID 42251842
- Real-world emergence of nirsevimab resistance in breakthrough infections with respiratory syncytial virus-B: a multicentre observational study in France. The Lancet. Microbe · 2 Jun 2026 PMID 42229496
- Infant respiratory syncytial virus (RSV) immunisation coverage in an Australian regional area, 1 May 2024 - 31 October 2025. Communicable diseases intelligence (2018) · 25 May 2026 PMID 42184438
- Effectiveness of nirsevimab immunisation after birth versus RSVpreF maternal vaccination in preventing RSV-related hospitalisations in infants: a population-based retrospective cohort study. The Lancet. Child & adolescent health · 10 May 2026 PMID 42107385
- Knowledge, attitudes, and practices of pediatricians in Crete, Greece, regarding RSV immunization: a cross-sectional study. European journal of pediatrics · 27 Apr 2026 PMID 42043589
Human data, design not indexed (7)
- Safety of nirsevimab in children aged 0-24 months: Analysis based on EudraVigilance data (2023-2025). Human vaccines & immunotherapeutics · 9 Oct 2026 PMID 42851207
- Comparing the potential impacts of seasonal immunisation against year-round immunisation to prevent RSV infant hospitalisations in Japan: A modelling study. Vaccine · 26 Aug 2026 PMID 42648051
- Effectiveness of RSV Prevention Strategies in US Infants: 2024-2025. Pediatrics · 3 Aug 2026 PMID 42547085
- Economic evaluation of a bivalent respiratory syncytial virus prefusion F vaccine for maternal vaccination in Sweden: cost-effectiveness and budget impact. Journal of medical economics · 8 Jun 2026 PMID 42258348
- First year of nirsevimab use in Argentina (2025): Report from a private vaccination center. Archivos argentinos de pediatria · 26 May 2026 PMID 42189590
- Modelling the impact of long-acting monoclonal antibody, maternal vaccine and hybrid programs of RSV immunisation in temperate Western Australia. Vaccine · 23 May 2026 PMID 42176437
- Post-licensure safety of nirsevimab from the Canadian National Vaccine Safety (CANVAS) network. Human vaccines & immunotherapeutics · 28 Apr 2026 PMID 42048598
Written from 22 PubMed abstracts, each one listed by PMID above. Published: 2026-06-15. Last written: 2026-08-26 by GPT. Drafted by language models from published abstracts; not medical advice.