Bupivacaine
Bupivacaine is a long-acting amide-type local anesthetic used to produce regional anesthesia and analgesia.
Bupivacaine is a long-acting amide-type local anesthetic used to produce regional anesthesia and analgesia. It acts primarily by blocking voltage-gated sodium channels in excitable tissues, thereby inhibiting the initiation and propagation of nerve impulses. Because of its relatively prolonged duration of action, it is widely used in surgical, obstetric, and pain-management settings.
Clinically, bupivacaine is valued for sustained local pain control, but its use is limited by dose-dependent systemic toxicity, particularly cardiotoxicity and central nervous system adverse effects if significant systemic absorption occurs. This safety profile has made bupivacaine an important reference compound in pharmaceutical development, especially in studies aimed at improving local delivery, reducing toxicity, or optimizing anesthetic precision.
Where the papers sit
9 papers from the last 6 months study bupivacaine directly · updated from PubMed 5 Oct 2026
Study type 3 clinical trials · 1 observational · 1 human data · 4 preclinical
Themes one subject
Those 9 are all about one subject.
-
Local Anesthetic Therapeutics
Local anesthetic therapeutics are moving toward longer, safer and more precisely delivered analgesia. Liposomes, lyotropic liquid crystals, microneedle patches and buccal films aim to sustain local action while limiting systemic exposure or adding tissue protection. Clinical work tests infiltration, plane blocks and perioperative regimens against opioid use, comfort and recovery, including comparisons with ropivacaine. Medicinal-chemistry studies target cardiotoxicity, while translational work extends local pain treatment to osteoarthritis and oral mucositis.
Papers
The 9 papers from the last 6 months that study bupivacaine directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Local Anesthetic Therapeutics (9)
- Modified scalp block and total intravenous anesthesia for frontal craniotomy in a dog with a meningioma: a technical case report. Veterinary research communications · 9 Sept 2026 PMID 42714672
- Phase-tunable lyotropic liquid crystals with low viscosity and improved safety for long-acting local anesthesia. International journal of pharmaceutics · 26 Aug 2026 PMID 42648564
- Targeting of tripartite neuron-cancer-immune cell crosstalk augments response to chemotherapy and immunotherapy. Cell reports. Medicine · 18 Aug 2026 PMID 42612638
- Liposomal bupivacaine versus ropivacaine for surgical site infiltration in lumbar fusion: a prospective randomized controlled trial. Annals of medicine · 27 Jul 2026 PMID 42504098
- Replacement of the Piperidine Ring with Aza-Spirocycles Reduces Cardiotoxicity of the Local Anesthetic Drug Bupivacaine. Journal of medicinal chemistry · 8 May 2026 PMID 42101190
- Triple-layered core-shell microneedle patch for sustained analgesic delivery and chondroprotection in osteoarthritis. Journal of controlled release : official journal of the Controlled Release Society · 2 May 2026 PMID 42069002
- The Role of Ultrasound-Guided Lipoma Plane Block with or without Adrenaline in Enhancing Anesthetic Precision, Patient Comfort, and Surgical Efficiency: A Prospective Randomized Controlled Trial. La Clinica terapeutica · 28 Apr 2026 PMID 42047122
- Liposomal Bupivacaine Reduces Opioid Use Following Third Molar Surgery: A Randomized Controlled Trial. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 26 Apr 2026 PMID 42036103
- Early-stage pharmaceutical development of bilayer buccal films with a chitosan backing layer for local pain management in oral mucositis. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 17 Apr 2026 PMID 41997306
By study type
Clinical trials (3)
- Liposomal bupivacaine versus ropivacaine for surgical site infiltration in lumbar fusion: a prospective randomized controlled trial. Annals of medicine · 27 Jul 2026 PMID 42504098
- The Role of Ultrasound-Guided Lipoma Plane Block with or without Adrenaline in Enhancing Anesthetic Precision, Patient Comfort, and Surgical Efficiency: A Prospective Randomized Controlled Trial. La Clinica terapeutica · 28 Apr 2026 PMID 42047122
- Liposomal Bupivacaine Reduces Opioid Use Following Third Molar Surgery: A Randomized Controlled Trial. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 26 Apr 2026 PMID 42036103
Observational studies and case reports (1)
- Modified scalp block and total intravenous anesthesia for frontal craniotomy in a dog with a meningioma: a technical case report. Veterinary research communications · 9 Sept 2026 PMID 42714672
Human data, design not indexed (1)
- Early-stage pharmaceutical development of bilayer buccal films with a chitosan backing layer for local pain management in oral mucositis. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 17 Apr 2026 PMID 41997306
Preclinical: animal, cell and lab studies (4)
- Phase-tunable lyotropic liquid crystals with low viscosity and improved safety for long-acting local anesthesia. International journal of pharmaceutics · 26 Aug 2026 PMID 42648564
- Targeting of tripartite neuron-cancer-immune cell crosstalk augments response to chemotherapy and immunotherapy. Cell reports. Medicine · 18 Aug 2026 PMID 42612638
- Replacement of the Piperidine Ring with Aza-Spirocycles Reduces Cardiotoxicity of the Local Anesthetic Drug Bupivacaine. Journal of medicinal chemistry · 8 May 2026 PMID 42101190
- Triple-layered core-shell microneedle patch for sustained analgesic delivery and chondroprotection in osteoarthritis. Journal of controlled release : official journal of the Controlled Release Society · 2 May 2026 PMID 42069002
Written from 9 PubMed abstracts, each one listed by PMID above. Published: 2026-06-24. Last written: 2026-07-29 by GPT. Drafted by language models from published abstracts; not medical advice.